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KMID : 1134820160450040501
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 4 p.501 ~ p.509
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Anti-Atopic Effects of Mixed Extracts from Date Plum, Persimmon, and Mulberry Leaves
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Cho Byoung-Ok
Yin Hong-Hua
Shin Jae-Young
Fang Chong-Zhou
Chang Che-Denis
Jang Seon-Il
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Abstract
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The present study investigated the anti-atopic effects of mixed extracts from date plum, persimmon, and mulberry leaves (DPME) on atopic dermatitis (AD)-like skin lesions in hairless mice. The in vivo results demonstrated that DPME treatment significantly reduced the dermatitis clinical score and epidermal thickness in AD-like skin lesions. Histological analyses showed that DPME treatment strongly inhibited dermal infiltration of inflammatory cells and activity of mast cells in AD-like skin lesions. DPME treatment inhibited production of serum IgE and interluekin (IL)-4 in hairless mice with AD. Moreover, DPME treatment significantly suppressed production of tumor necrosis factor (TNF)-α and IL-6 cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 human mast cells. In addition, DPME treatment reduced production of pro-inflammatory mediators (nitric oxide, prostaglandin E2, TNF-α, and IL-6) in lipopolysaccharide-stimulated RAW 264.7 macrophages. Therefore, the results of this study indicate that the anti-atopic and anti-inflammatory effects of DPME may be involved in the regulation of inflammatory responses, suggesting that DPME may be used as an anti-atopic dermatitis material and natural anti-inflammatory ingredient.
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KEYWORD
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date plum leaves, persimmon leaves, mulberry leaves, atopic dermatitis, inflammation
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